Human genetic background in susceptibility to tuberculosis
نویسندگان
چکیده
منابع مشابه
Human genetic susceptibility to tuberculosis.
INTRODUCTION Recent advances in the understanding of human susceptibility to tuberculosis have resulted from the application of molecular techniques to answer mechanistic questions on genetic regulation of host defense. METHODS This review is based upon a MEDLINE search of articles relevant to human genetic susceptibility to mycobacteria. RESULTS The impact of natural selection in shaping s...
متن کاملKIR-HLA combinations and susceptibility to tuberculosis
Introduction: Tuberculosis (TB), caused by Mycobacterium Tuberculosis (Mtb), with more than nine million new cases and almost two million deaths in each year is a worldwide important public health problem. Generally, human immune responses prevent Mtb spread, and the infection remains in a latent state. Both, innate and adaptive immune responses are involved against TB. However, the role of the...
متن کاملGenetic background affects susceptibility to tumoral stem cell reprogramming
The latest studies of the interactions between oncogenes and its target cell have shown that certain oncogenes may act as passengers to reprogram tissue-specific stem/progenitor cell into a malignant cancer stem cell state. In this study, we show that the genetic background influences this tumoral stem cell reprogramming capacity of the oncogenes using as a model the Sca1-BCRABLp210 mice, where...
متن کاملGenetic Background Influences Susceptibility to Chemotherapy-Induced Hematotoxicity
Hematotoxicity is a life-threatening side effect of many chemotherapy regimens. Although clinical factors influence patient responses, genetic factors may also play an important role. We sought to identify genomic loci that influence chemotherapy-induced hematotoxicity by dosing Diversity Outbred mice with one of three chemotherapy drugs; doxorubicin, cyclophosphamide or docetaxel. We observed ...
متن کاملGenetic susceptibility to tuberculosis in Africans: a genome-wide scan.
Human genetic variation is an important determinant of the outcome of infection with Mycobacterium tuberculosis. We have conducted a two-stage genome-wide linkage study to search for regions of the human genome containing tuberculosis-susceptibility genes. This approach uses sibpair families that contain two full siblings who have both been affected by clinical tuberculosis. For any chromosomal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Mycobacteriology
سال: 2020
ISSN: 2212-5531
DOI: 10.4103/ijmy.ijmy_118_20